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Although not much is known about these enzymes in cancer, the CHAC2 isoform has already been classified as a tumour suppressor gene in gastric and colorectal cancer, on the basis of its downregulation being associated with more aggressive cancer variants and its activation-inducing apoptosis in cancer cells
Another concern with GLP-1 agonists is the loss of body mass, including fat and skeletal muscle, causing some patients to feel a loss of strength
A genome-wide CRISPR/Cas9 screening found that the loss of Kelch-like ECH-associated protein 1 (KEAP1) (464) and SGOL1 (465) promote drug resistance in cancer cells, and the CRISPR-induced deletion of SLFN11 (466), BAK (467), and any CST complex members (468) can initiate drug resistance in cancer cells
