Similarly, in the United Kingdom Prospective Diabetes Study (UKPDS), only 34% of patients attained an A1c age 65) and patients with hepatic or renal disease are more likely to experience frequent and severe hypoglycemic reactions, particularly if the goals of therapy aim for inappropriately tight glycemic control (20)
GLP-1 RA initiation was associated with about 23 additional suspected drug-induced acute pancreatitis cases per 100,000 patients, but with about 17 fewer hypertriglyceridemia-associated cases and about 10 fewer alcohol-induced cases per 100,000 patients
Some patients also report feeling less emotionally reactive to things they usually enjoy, Corrado says, though more research is needed
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Individuals with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use GLP-1 agonists