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These neurons send widespread projections to brain regions that highly express GLP-1Rs [66, 69], where administration of GLP-1R agonists reduces food intake and GLP-1R antagonists increase food intake such as the bed nucleus of the stria terminalis (BNST) as a notable example [70] (Fig

Albiglutide is the second long-acting GLP-1 approved by the FDA in 2014 with 97% homology

Approval standards, manufacturing requirements, and interchangeability rules could all influence adoption rates

Excessive consumption may have a laxative effect

However, to promote significant muscle or bone growth, a higher dose may be warranted