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However, it has been recently described that mTORC2 also possesses tyrosine phosphorylation capacity [118], and that it phosphorylates tyrosines on IRS and tyrosine kinases in both receptors, IGF-1 and IR, thus reinstituting the signal of the activated receptors [118]

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any change in regulation still requires FDA rulemaking for the individual compounds

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Unlike some oral medications that require specific timing relative to meals for optimal absorption, tirzepatide is administered as a subcutaneous injection, which bypasses the gastrointestinal tract for absorption