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497 Moreover, with respect to calcific aortic valve diseases, which is one of the most widespread heart valve disorders, the expression of ZIP13 is markedly enhanced

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These individual unimolecular multi-agonists activities seemed to harmonize the overall metabolic efficacy, which predominantly results from synergistic glucagon action to increase energy expenditure, GLP-1 action to reduce caloric intake and improve glucose control, and GIP action to potentiate the incretin effect and buffer against the diabetogenic effect of inherent glucagon activity

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