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Gradual Dose Increase for Better Tolerance If you experience nausea or other side effects, you may need to increase your dose more slowly than the standard schedule

13-15 Use of common migraine preventive therapies, such as topiramate, propranolol, and amitriptyline, for a duration of 8 weeks, reportedly reduced plasma glutamate levels as compared with levels in individuals with migraine before preventive treatment

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