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Immunotherapy of melanoma

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The authors compile data showing GHK-Cu modulates expression of more than 4,000 human genes including substantial upregulation of antioxidant defense genes, DNA repair genes, and genes encoding collagen and elastin biosynthesis enzymes while downregulating pro-inflammatory and tissue-degradation pathways

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However, the absence of cysteine leads to insufficient GPX4 synthesis, increased expression of wild-type p53, and increased cell sensitivity to ferroptosis (Ji et al., 2021)

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doi: 10.1097/mca.0000000000000830 13 SilverHJOlsonDMayfieldDWrightPNianHMashayekhiMet al

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doi:10.1074/jbc.M007874200

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