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Discussion The in vivo study demonstrated that lidocaine could be slowly released from the lidocaineepirubicinlipiodol emulsion and the randomized clinical trial showed that pain scores were significantly lower in patients who received intraarterial lidocaine injection by the W/O technique at T 0 , T 4 , T 8 , and T 24 after the procedure compared to patients who received an intraarterial bolus injection of lidocaine