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ACs influence immune responses by modulating inflammatory cytokine production [16], while mitochondrial dysfunction exacerbates oxidative stress and inflammatory signaling [17]

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Effects of virtual reality-based activities of daily living rehabilitation training in older adults with cognitive frailty and activities of daily living impairments: a randomized controlled trial

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Thus, the -glutamyl cycle, apart from explaining the synthesis and degradation of glutathione, may serve as a generator of signals to activate amino acid transport into cells (2, 75)