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Complications of diabetes: complex pathophysiological changes Diabetes, as a chronic metabolic disease, starts with hyperglycemia and induces complex pathophysiological changes in the body, including hyperglycemia stress, mitochondrial dysfunction and ER stress.These factors influence each other to form a complex network of cellular and molecular signals (Fig

Glutathione reductase (GR), a dimeric flavoprotein, is encoded by the GSR gene and is found in various tissues

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doi: 10.1111/dmcn.13114 51 BroscoJPSandersLMDhariaRGuezGFeudtnerC

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