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Underlying medical risks: Certain health conditions, medications, or personal medical histories can make GLP-1 therapy unsafe

Endothelium microenvironment sensing leading to nitric oxide mediated vasodilation: a review of nervous and biomechanical signals

N Engl J Med 2022;387:20516.ArticlePubMed 10

The Hers and Hims GLP-1 programs work best if you meet a specific set of circumstances: You have a BMI of 30+ or 27+ with health conditions like high blood pressure or polycystic ovarian syndrome (PCOS) You prefer virtual care and dont need weekly check-ins You want bundled support for nutrition, sleep, and exercise, not just medications Its especially helpful for people whove tried lifestyle changes but feel hunger, cravings, or metabolic issues are holding them back

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