Found operates on a broader practitioner network model, connecting patients with available providers (MDs, NPs, PAs) who may rotate or vary
29 Axonal Degeneration Disrupts Neural Connectivity and is a Key Early Contributor to the Pathogenesis of ALS Mechanisms of Axonal Degeneration Excess activation of glutamatergic, nicotinic, or voltage gated calcium channels drive influx of calcium from the extracellular space into cell Oxidative or ischemic stress drives calcium efflux through NCX channel from mitochondria Increased cytosolic calcium and cADPR Excess cytosolic calcium activates calpain-2 which cleaves cytoskeletal proteins activate the ER membrane ryanodine receptor, (NfL, others) and membrane-associated proteins (alpha-II spectrin) resulting in releasing the ER calcium store into the cytosol decreased axon stability and increased degradation (e.g., increased SBDP-145) AMPA=-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Glutathione is one of the body's most powerful antioxidants, playing a vital role in detoxification, immune defense, and cellular repair[4]
4 Preclinical studies of GLP-1 RAs have shown promising antitumor activity in breast cancer, though it is unclear whether these effects are direct or indirect via energy restriction
Ontarios HART Hubs vs Harm Reduction | Ontario is shifting its addiction response with the rollout of HART Hubs short for Homelessness and Addiction Recovery Treatment Hubs while moving away from supervised consumption services, safer supply, drug checking, and needle exchange programs
