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Furthermore, GLP-1 RAs have demonstrated significant reductions in major adverse cardiovascular events (MACE), heart failure hospitalizations, and all-cause mortality in patients with T2DM, and obesity, benefits not consistently observed with CPAP in randomized cardiovascular outcome trials [25,26,27]

Constipation is another common issue, reported in 21-25% of retatrutide users and a significant percentage of cagrilintide users