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These combined effects help improve glycaemic control and often result in significant weight loss, though weight management is not a licensed indication in the UK

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Some medications also reduce B12 absorption (Sobczyska-Malefora et al., 2021) among the main ones are: metformin, proton pump inhibitors (PPIs), such as omeprazole, lansoprazole and esomeprazole, and H2-receptor antagonists, such as ranitidine, cimetidine, famotidine and nizatidine

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This type of B12 is more difficult for the body to digest