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The 19S regulatory particle plays essential roles in processing ubiquitylated substrates by binding, deubiquitinating, and unfolding ubiquitinated proteins ( The proteasome has been demonstrated as a potential therapeutic target for cancer

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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Berglund LM, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, et al