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Muscle catabolism: Extended duration, especially at high intensity, may push the body to use muscle protein for energy, causing muscle loss

You dont always need both, but many people benefit from a combination, especially during high-demand seasons like pregnancy, breastfeeding, or chronic stress

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Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121

doi: 10.1007/s12672-021-00439-0