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[14] Serious systemic side effects have not been reported

doi: 10.1016/S0304-3959(00)00482-6

While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

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Pain doctors and neurologists have used Botox to treat and prevent chronic migraines for some time