Side effects are more likely to start or worsen: Retatrutide side effects may last a few days, several weeks or longer
Common adverse effects of GLP-1 receptor agonists include: Gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation) Injection site reactions Headache Fatigue Dizziness Important safety considerations include: Risk of hypoglycaemia when used with insulin or sulfonylureas (dose reduction of these agents may be needed) Potential worsening of diabetic retinopathy with semaglutide in patients with pre-existing retinopathy Risk of dehydration and acute kidney injury from persistent vomiting or diarrhoea Pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (observed in rodent studies, though human relevance remains uncertain) Patients should be counselled about persistent severe abdominal pain as a potential warning sign of pancreatitis requiring immediate medical attention
Many chemical reactions take place in the mitochondria, involving hundreds of substances, enzymes, and ions
Less food being consumed due to reduced appetite can cause fatigue, dizziness and headaches, which can in turn be made worse when dehydration is added into the mix
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