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Many patients also experience what has come to be called Ozempic face: a hollowing and aging of the midface caused by the loss of facial fat that comes with significant weight loss

The Link Between Obesity, Metabolic Disease and Inflammation Visceral fat actively secretes pro-inflammatory cytokines and adipokines, and significant weight loss as seen with retatrutide in Phase 2 trials is biologically plausible to reduce these markers, though direct anti-inflammatory effects remain unconfirmed

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