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Someya S, Kim MJ

Therefore, some of these protein antioxidant systems, together will glutathione, may contribute thiols to reduce the effective concentration of AX within the cell and both, the system involved and the ratio of conversion may depend on the subcellular compartment where the reaction occurs

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Chem Biol 2008

This seems mediated not only by the reduction in ROS accumulation and the subsequent DNA damage, but also by the direct bond between GSH and drugs that may favor their excretion or may lead to non-effective compounds [115]