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In preclinical studies, blocking NNMT in fat tissue lowered a metabolite called 1-MNA and raised intracellular NAD+ and SAM, which researchers link to reduced fat storage in adipocytes

HELP FOR PERNICIOUS ANAEMIA/B12 DEFICIENT PATIENTS AND OTHERS WISHING TO SELF-INJECT B12 ALWAYS MAINTAIN STRICT HYGIENE WHEN SELF-INJECTING

Intramuscular injection near an injury site (a common self-administration approach) adds a theoretical local concentration benefit that has some support in animal wound models but has not been tested head-to-head against subcutaneous delivery in a controlled trial

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He received a diagnosis of B 12 deficiency 10 years ago, and during the covid-19 pandemic he switched from intramuscular hydroxocobalamin 1000 mcg once monthly to oral B 12 supplementation