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After oral treatment with betanin, they found that followed by a significant increase of glycolytic enzyme (glucokinase and pyruvate kinase), glucose6phosphate dehydrogenase, and decrease in the activity of gluconeogenic enzymes (glucose6phosphatase and fructose1,6bisphosphatase), the levels of plasma glucose, insulin, glycosylated hemoglobin (HbA1c), and hemoglobin (Hb) were restored in diabetic rat

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