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We recently found that targeting BET proteins induces glutamate dehydrogenase 1 (GDH1)-dependent glutamine metabolic remodeling in liver cancer, where glutamine-derived -KG through GDH1 maintains cancer cell survival when glycolysis is compromised 23 , but the underlying mechanisms are not fully understood

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Zhao L, Liu D, Ma W, Gu H, Wei X, Luo W, Yuan Z

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Depending on the dose, a fraction of APAP is converted into a highly reactive toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), by several P450 cytochromes [34]

[DOI] [PubMed] [Google Scholar] 3.Bavarsad Shahripour R., Harrigan M.R., Alexandrov A.V