[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Kraus D., Yang Q., Kong D., Banks A.S., Zhang L., Rodgers J.T., Pirinen E., Pulinilkunnil T.C., Gong F., Wang Y.C., et al
However, the foundational mechanism paper (Benoist et al., 2014 in J Pharmacol Exp Ther) establishing Dihexas HGF/c-Met pathway activation was formally retracted in April 2025 after being flagged since 2021
Because NNMT activity has been linked with obesity-related metabolic patterns, NNMT inhibition is studied as a way to improve metabolic efficiency in adipose tissue
The identification of novel biomarkers, such as melatonin metabolites, oxidative catabolites, DNA methylation patterns, and circulating miRNAs, represents a critical step toward developing reliable tools for early detection and individualized risk stratification 2
Human and rat results should therefore be shown separately and should not be combined into one cross-species ranking