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Using selected doses and time point for ASA toxicity, we have demonstrated that when GSH synthesis is inhibited in HepG2 cells by buthionine sulfoximine (BSO), prior to ASA treatment, cytotoxicity of the drug is augmented

10.1016/S0140-6736(05)67423-5 44 GoycooleaM

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Specifically, we defined a percentage BMI change phenotype as: where BMI 1 and BMI 2 represent pre-treatment and post-treatment BMI, respectively, measured in weight in kilograms per height in metres squared