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IGF-I signaling is important in skeletal muscle maintenance and repair IGF-I can reverse various muscle wasting conditions in experimental models The potential therapeutic effect of novel IGF-I formulations and biodegradable IGF-I variants must be explored in clinical trials Acknowledgements This work was supported by the project for the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

A cutoff of 10 M was chosen for the initial screening (Figures 3B,C)

However, the precise contribution of each receptor system to overall efficacy and the potential for receptor-specific side effects remain active areas of investigation in ongoing clinical trials

Using it to induce immunogenic cell death (ICD) and anti-immunosuppression [81]

hydrophila , where all treated fish showed significant protection