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Ruptured ferroptotic cells trigger innate immunity by releasing damage-associated molecular pattern molecules (DAMPs), such as heat shock proteins (HSPs) and oxidized lipids, upon tissue damage or tumor therapy ( Composed of B cells, T cells, and their secreted products, adaptive immunity is responsible for recognizing and clearing pathogens or abnormal cells specifically and forming immune memory ( 2.1 Macrophages Macrophages, which form a pivotal element of the innate immune system, are imperative for several facets of inflammatory processes, phagocytosis of debris, and tissue repair ( Figure 2 )
Am J Physiol Heart Circ Physio 299:H788H798 Gergs U, Bernhardt G, Buchwalow IB, Edler H, Frba J, Keller M, Kirchhefer U, Khler F, Milinger N, Wache H, Neumann J (2019) Initial characterization of transgenic mice overexpressing human histamine H 2 receptors
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Polyphenol-rich extracts (e.g., curcumin, resveratrol) improve endothelial function in early-stage diabetes, likely due to their pleiotropic effects beyond mere ROS scavenging (Mohd-Nor et al., 2022)
