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MOTS-c addresses the root cause of energy decline at the cellular level

Together they drive expression of nuclear-encoded mitochondrial genes, increasing both the number and efficiency of mitochondria in muscle and cardiac tissue

Ethanol-induced oxidative stress can impair tyrosine hydroxylase activity, reducing dopamine production, similar to serotonin synthesis

doi:10.1523/JNEUROSCI.1779-09.2009 Kurz T, Gustafsson B, Brunk UT (2006) Intralysosomal iron chelation protects against oxidative stress-induced cellular damage

The nodose ganglions (NGs) and brains were collected, postfixed in the same fixative for 2 h to overnight at 4 C, and incubated in phosphate buffer containing 30% sucrose for 48 h