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From a clinical perspective, the lack of large-scale human trials means it cannot yet be considered an established therapy

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In addition, the first-line medications for patients with osteoporosis consist of bisphosphonates (BPs), selective estrogen receptor modulators, parathyroid hormone analogs, and therapeutic doses of calcium and vitamin D, which improve bone quality by inhibiting bone resorption, promoting bone formation, and supplementing bone nutrition (30)