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In the Phase 2 trial, the cohorts that escalated to higher maintenance doses began at 2mg weekly and increased by 2mg every 4 weeks

From there, the dose was gradually increased every 4 weeks

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How Sleep Deprivation Slows Weight-Loss Metabolism Poor sleep can seriously sabotage your weight loss efforts, even when you're doing everything else right

If nausea becomes severe enough to interfere with eating adequate protein or forces you to skip doses, discuss dose reduction or slower escalation with your provider