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Elevated mean arterial pressure with RT reported in this study is of note due to the more frequently reported blood pressure lowering effects of RT reported across the literature, particularly in hypertensive individuals (Thomas et al., 2021)

however, these drugs have failed to modify or significantly slow disease progression

Among the remaining subjects, we further excluded those who received a diagnosis of bipolar disorder during the follow-up assessment (n = 9), those with missing metabolite data due to the lack of blood samples (n = 158) and those who did not complete the Inventory for Depressive Symptoms questionnaire (n = 33)

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