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Moreover, DHA enhanced the degradation of ferritin and elevated the free iron pool to regulate iron homeostasis in a lysosome and autophagy manner by regulating the activity of the AMPK/mTOR/p70S6k signaling pathway in leukemia cells (Su et al., 2021)

Both NAPQI and ROS cause mitochondrial DNA damage, activation of the JNK signaling pathway, which further amplifies the mitochondrial ROS production, and causes the mitochondrial permeability transition (MPT) pore to open (Iorga et al., 2017)

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However, a role for circulating liver-derived IGF-I could not be excluded

Anal Chem 89(7):40774084 Heilemann M, Van d LS, Schttpelz M, Kasper R, Seefeldt B, Mukherjee A, Tinnefeld P, Sauer M (2010) Subdiffraction-resolution fluorescence imaging with conventional fluorescent probes