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In this regard, inappropriate activation of estrogen receptor alpha signaling concomitantly with the elevation of testosterone has been demonstrated to trigger prostate cancer and prostate hyperplasia in mice [27]
Combined, the activities of CYP1A2 and CYP3A4 are comparable to that of CYP2E1, thus it is important to appreciate that these two enzymes can indeed contribute significantly to microsomal ethanol oxidation and thus, are likely to also contribute to the pathophysiology associated with hepatic ethanol oxidation
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