Conclusion This clinical trial provides robust evidence supporting the benefits of long-term GSH supplementation in improving oxidative stress and glycemic control in T2DM patients
Previously, starting dose was IV-only in a clinical setting, with transition to IV/subcutaneous maintenance after 18 months
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Upregulation of iron transport proteins such as transferrin (Tf), transferrin receptor (TfR), and divalent metal transporter 1 (DMT1) enhances cellular iron uptake, while loss or dysfunction of ferroportin 1 (FPN1) hampers iron efflux, leading to intracellular iron overload and oxidative damage
doi:10.7326/0003-4819-134-2-200101160-00015