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The severity of these reactions led to an 18% discontinuation rate in the clinical trial, indicating that nearly one in five patients cannot tolerate the treatment protocol

Rotate injection sites consistently, never using the same spot twice in a row

Patients may also experience associated symptoms such as hoarseness, chronic cough, or a feeling of a lump in the throat

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Moreover, flow cytometry revealed that the number of FAPCAR-positive T cells was increased in both spleens and lungs after CD5/ LNP-FAPCAR 2.2 treatment (Fig