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It is noteworthy that supplementation with iron-modulating agents does not effectively reduce hepatic iron stores and is anticipated to garner significant interest as a novel therapeutic strategy for addressing the pathogenesis of hemochromatosis [108, 109]

Further, NRF1 has been shown to be important for the survival of hepatocytes and to mediate oxidative stress during development 62,63

Vitamin C deficiency can lead to scurvy, a condition characterized by fatigue, weakness, gum disease and skin abnormalities

doi: 10.1016/0003-9861(81)90215-0

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