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Aging Pathobiology and Therapeutics (2022) 4

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Subcompartments such as the mitochondrial matrix and intermembrane space, cytosol in neurons and astrocytes, endothelium, and the extracellular space (interstitium and basal lamina) are represented, allowing modeling of cross-compartment processes such as transport and exchange

Furthermore, NRF2 was also found to regulate the expression of thioredoxin 1 (TXN1) and thioredoxin reductase 1 (TXNRD1), which can reduce oxidized protein thiols [25, 26]