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& Graves, J
Gastrointestinal effects predominate: | Side Effect | Orforglipron | Oral Semaglutide | Tirzepatide | |-------------|-------------|-----------------|-------------| | **Nausea** | 22-28% | 24-28% | 24-31% | | **Vomiting** | 8-12% | 10-14% | 9-13% | | **Diarrhea** | 14-18% | 12-16% | 14-21% | | **Constipation** | 10-14% | 8-12% | 11-15% | | **Dyspepsia** | 6-9% | 8-11% | 5-8% | | **Discontinuation due to AEs** | ~6-8% | ~7-9% | ~4-7% | A notable difference: oral semaglutide has higher rates of upper GI symptoms (reflux, dyspepsia) because the SNAC formulation makes direct contact with gastric mucosa
If the homeostasis gets interrupted and your microbiome becomes out of balance, you develop gut dysbiosis with more harmful bacteria than beneficial ones
Yes, Vyvanse and Adderall are addictive, especially when not used as prescribed
The panel brought together experienced voices including John Cumming, MD, MBA, Stephan Drner, and Kjrk Reyerson from Medical Alley
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