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Persistent Urine Color Changes and Associated Symptoms While temporary color shifts are often harmless, persistent changes especially when accompanied by pain , burning , or cloudiness may indicate medical conditions such as: Urinary tract infections (UTIs) Kidney disorders Liver dysfunction Urine that appears dark, cloudy, or foul-smelling could signal an infection or inflammation in the urinary tract

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Biochim Biophys Acta 1853:308316