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Among other things, it is mentioned that the occurrence of ferroptosis can exacerbate myocardial hypertrophy ( 2+ , generating large lipid peroxide (LPO) volumes ( 2+ levels together with higher levels of ROS production, mitochondrial phenotypes consistent with ferroptosis including decreased cristae and a smaller volume, and reductions in the expression of GPX4, GSH, FSP1, and CoQ10

Alongside its regulation of glucose homeostasis and lipid metabolism, the histone deacetylase sirtuin (SIRT1) has been reported to act as a negative regulator of mTORC1

Figure 4 4.3 Common programmed cell death pathways in GC Cell death is a fundamental biological process essential for maintaining tissue homeostasis and suppressing tumor initiation and progression

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