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The lack of multi-drug delivery platforms and long-term stability further restricts the clinical utility of PLGA nanosystems

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The STEP clinical trials demonstrated that semaglutide produced average weight loss of 15% over 68 weeks, while tirzepatide achieved 2022% in similar studies

Detailed biophysical studies (X-ray crystallography, EPR, NMR) elucidated that in GHK-Cu, the Cu(II) ion is coordinated by the imidazole side chain nitrogen of histidine, the alpha-amino nitrogen of glycine, and the deprotonated amide nitrogen of the glycine-histidine bond