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doi:10.1146/annurev-physiol-021113-170343 Johnson RJ, Rideout BA

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The functional expansion of Nrf2 in proliferating cells directs the enhancement of anabolic metabolism, maintains redox homeostasis and further promotes the activation of PI3KAkt signaling, suggesting the presence of positive feedback between Nrf2 and the PI3KAkt pathway in proliferating cells (Figure 9)

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The increasing prevalence of obesity and metabolic disorders has created a pressing need for innovative treatments, making retatrutide a focal point of ongoing research in the medical community