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Unscheduled synthesis, as measured by the number of grains in non-S phase cells and defined as an excess in the normal duplication of the genome prior to mitosis, increased in the lens epithelium to 8.3x control following in vivo exposure to 6 kJ/m2 of UV (Soderberg et al., 1986)

doi: 10.1016/j.jconrel.2022.03.021

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FIGURE 6 Instead of applying light and photosensitizers to achieve efficient cancer therapy, SDT employs ultrasound (US) and sonosensitizers to trigger 1 O 2 or OH generation, exerting a crucial role in ablation of tumor tissue that is hard to reach through light irradiation