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MSCs with high GSH levels have improved hyaline cartilage regeneration in vivo To confirm that the highly functional stem cells isolated using FreSHtracer had regenerative effects on cartilage defects in vivo, we generated a 4-mm-diameter chondral defect in the trochlear groove of rabbits and compared the cartilage regenerative efficacy of GSH-high and GSH-low hES-MSCs

doi: 10.1039/C3FO60277J

The substance is broadly safe in topical use at typical formulation concentrations of 0.05 to 0.2 percent

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