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The median age of melanoma diagnosis is 59 years, however, in women aged 2529 years, melanoma is the most common type of cancer , and among women aged 3034 years, it is the second most common type of cancer after breast cancer

Cohort studies and genetic data analyses further support the preventive and therapeutic potential of GLP-1RAs against CRC (75,212)

Antioxidants and mitochondrial stabilisers such as coenzyme Q10 and MitoQ have shown potential in reducing ROS-mediated injury, while HDAC inhibitors and DNA methyltransferase modulators are being explored to reverse maladaptive epigenetic changes [32,41]

This minimal absorption occurs primarily through passive diffusion (paracellular and transcellular diffusion) in the small intestine, while the remaining EGCG reaches the colon to be degraded by intestinal microbial enzymes (198, 200, 201)

They emphasize that GLP-1RAs provide more weight loss than lifestyle modifications alone