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Subsequent engineering by Novo Nordisks Lotte Knudsen produced liraglutide and then semaglutide a once-weekly injection that binds to albumin in the blood for sustained action

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Paul Edison, a professor of science at Imperial College London, said in a news release

Researchers who have studied it understand the core mechanism: GLP-1 receptor (GLP-1R) agonism produces glucose-dependent insulin secretion from pancreatic beta cells, suppresses glucagon release from alpha cells, slows gastric emptying, and engages hypothalamic appetite circuits specifically the arcuate nucleus to reduce caloric intake through neuropeptide Y/AgRP suppression and POMC/CART activation

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