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Other lines of evidence also suggest that GLP-1 may have additional effects other than the well-known acute insulin secretion stimulation

Heres what we see most often with Josie members : Nausea (especially after eating too fast or too much) Bloating or fullness Constipation or looser stools Fatigue, especially in the first 12 weeks Appetite changes (most women eat less without feeling deprived) These usually improve over time, especially with the right dose and support

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10.1038/ncomms11624 [DOI] [PMC free article] [PubMed] [Google Scholar] Korshunov KS, Blakemore LJ, Trombley PQ (2017) Dopamine: a modulator of circadian rhythms in the central nervous system

Patients with type 2 diabetes, obesity, and elevated uric acid levels may see the greatest benefit