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doi: 10.3389/fphar.2023.1303844 Received 28 September 2023 Accepted 30 November 2023 Published 11 December 2023 Volume 14 - 2023 Edited by Alessio Squassina, University of Cagliari, Italy Reviewed by Michele Mazzanti, University of Milan, Italy Yashmin Choudhury, Assam University, India Updates Copyright 2023 Greco, Coperchini, Croce, Magri, Teliti and Rotondi

Furthermore, evidence shows that most (up to 95%) pharmaceutical drugs found effective and safe in animal studies fail in subsequent clinical phases in human populations, mainly due to insufficient efficacy, toxicity, and the emergence of unacceptable adverse drug reactions, raising significant concerns for ethical and economic reasons (204211)

10.1007/s10067-012-2011-7

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