Monitoring of volume status and renal parameters is advisable Poorly controlled hypertension , where the interaction between retatrutide and existing antihypertensive regimens may be unpredictable A history of pancreatitis : in line with UK Summary of Product Characteristics (SmPC) wording for approved GLP-1-based therapies such as semaglutide (Wegovy) and tirzepatide (Mounjaro), retatrutide should be used with caution in patients with a history of pancreatitis, and discontinued promptly if acute pancreatitis is suspected Thyroid C-cell tumours : rodent studies with GLP-1 receptor agonists have identified C-cell hyperplasia and tumours
While GLP-1 medication prices are gradually coming down and availability is improving, these treatments remain frustratingly out of reach for many families who could benefit from them
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It is especially relevant for patients taking or researching semaglutide, tirzepatide, GLP-1 injections, oral GLP-1 options, or physician-supervised weight loss programs
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