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For experiments in 384-well plates, 500 cells were seeded per well, and after 24 h, the medium was switched using a series of 4 aspirationwash steps with the desired final medium using Multidrop Combi (Thermo)

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mtROS and oxidized mtDNA serve as potent triggers of the NLRP3 inflammasome, leading to caspase-1 activation and IL-1 secretion ( Leishmania spp

What we are developing could be used as something like maintenance therapy where you could get subcutaneous injections every 3 to 6 months. The market opportunity also resulted in a dramatic legal battle between Pfizer and Novo Nordisk last year, when the two companies fought over buying Metsera, a start-up developing weight-loss drugs

Electroacupuncture can inhibit ferroptosis and treat neuropathic pain by regulating the SAT1/ALOX15 pathway, providing a new therapeutic target for neuropathic pain